ICR-Induced Frameshift Mutations in the Histidine Operon of Salmonella
نویسندگان
چکیده
منابع مشابه
Ultraviolet-induced reversions of Salmonella his frameshift mutations.
Ultraviolet (UV) light elicits reversions in 12 his frameshifts that also revert in response to ICR191. Reversion also is stimulated by UV in two of four spontaneously revertible, but ICR-negative, frameshifts.
متن کاملDNA sequence changes of mutations altering attenuation control of the histidine operon of Salmonella typhimurium.
The DNA sequence changes of 31 mutations altering the attenuation control mechanism of the histidine operon are presented. These mutations are discussed in terms of a model for operon regulation that involves a his leader peptide gene whose translation regulates formation of alternative stem-loop structures in the his leader messenger RNA. Three suppressible mutations generate nonsense codons (...
متن کاملDNA sequences of frameshift and other mutations induced by ICR-170 in yeast.
ICR-170-induced mutations in the CYC1 gene of the yeast Saccharomyces cerevisiae were investigated by genetic and DNA sequence analyses. Genetic analysis of 33 cyc1 mutations induced by ICR-170 and sequence analysis of eight representatives demonstrated that over one-third were frameshift mutations that occurred at one site corresponding to amino acid positions 29-30, whereas the remaining muta...
متن کاملInternal promoter P2 of the histidine operon of Salmonella typhimurium.
The histidine operon internal promoter P2 allows initiation of transcription at a rate up to one-third that of the wild-type his operon.
متن کاملMutational analysis of the histidine operon promoter of Salmonella typhimurium.
We isolated a collection of 67 independent, spontaneous Salmonella typhimurium his operon promoter mutants with decreased his expression. The mutants were isolated by selecting for resistance to the toxic lactose analog o-nitrophenyl-beta-D-thiogalactoside in a his-lac fusion strain. The collection included base pair substitutions. small insertions, a deletion, and one large insertion identifie...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1970
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.101.2.490-504.1970